Epigenetics

  • DNA-methylation Copyright: Christoph Bock (Max Planck Institute for Informatics)In biology, epigenetics is the study of heritable changes in gene activity which are not caused by changes in the DNA sequence. The term also refers to functionally relevant changes along the genome that do not involve a change in the nucleotide sequence.
  • It has been identified that several lifestyle factors such as diet, obesity, physical activity, tobacco smoking, alcohol consumption, environmental pollutants, psychological stress and working on night shifts might modify epigenetic patterns.
  • Experimental data show that early-life events influence later risk for several diseases such as metabolic, cardiovascular and mental diseases. During critical periods of prenatal and postnatal development, nutrition and stress can impact developmental pathways and thereby induce lasting regulatory changes predisposing to disease. This dysregulation appears to be mediated, at least in part, by epigenetic processes such as histone modifications and DNA methylation.
  • Researchers from Making Genetics are experts in genomics applied to the study of DNA methylation and gene expression regulation.
  • Making Genetics offers epigenomic services. This section contains the development of diagnostic tools for third parties using DNA methylation as a biomarker. Focusing on key diseases and biological states directly related such as pregnancy, aging, cancer, immune system, inflammation, metabolic syndrome, neurology, psychiatry or nutrition. In addition, we are currently developing a line of services for research based on predesinged epigenetic panels for neurodegenerative and metabolic diseases. 
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