Among the services we offer in Making Genetics are the analysis of genomic data from NGS, microarrays, as well as biological interpretation of the results and complete analysis on demand:

ANALYSIS OF SAMPLES THROUGH THIRD PARTIES

The determination of samples in any genomic reference technology is offered:  Genomics: Medium-high performance genotyping services using different technologies such as Epityper, Fluidigm, Array and Resequencing (exome, gene panels or specific regions of the genome).  Epigenomics: Determination of DNA methylation in a massive way (arrays, RRBS, MeDIP-Seq, etc.) or specific to a region (Epityper, target BS-Seq by NGS, etc).  Transcriptomics: Analysis of gene expression using array technology (Illumina, Affymetrix) or RNA-seq for the determination of mRNA or microRNAs, etc.

ANALYSIS OF GENOMIC DATA FROM MASSIVE SEQUENCING

ANALYSIS OF GENOMIC DATA FROM NGS  Resequencing (exome or panels of genes or specific regions of the genome). It includes preprocessing of data, quality analysis, assembly of genomes from a reference, identification of polymorphisms (SNPs) and / or mutations from sequencing and genomic association with the phenotype of interest.  Transcriptomic (RNA-Seq, smallRNA-Seq,). Expression or differential methylation analysis and gene discovery from RNA-seq data. It includes preprocessing of data, quality analysis, assembly, normalization, sequence annotation and quantification of differential expression.  Epigenomics (BS-Seq, RRBS, MeDIP-Seq, MBD-Seq, TAB-Seq, OxBS-Seq, ChIP-Seq of histones, transcription factors and other proteins that bind to DNA). Methylation analysis or differential enrichment from NGS data. It includes preprocessing of data, quality analysis, assembly, normalization, sequence annotation and quantification of methylation or differential enrichment.

DATA ANALYSIS OF MICROARRAYS

Analyzes from microrayray technology of genomic, transcriptomic and epigenomic data from the main commercial brands (Affymetrix, Agilent and Illumina). Pre-processing, quality analysis, and data normalization are included. In addition, studies of genetic association and complete genome (GWAS), expression and differential methylation are offered.

BIOLOGICAL INTERPRETATION

It also offers the possibility of performing the biological interpretation of the data (analysis of signaling pathways, mapping and tracking of sequences from both NGS and microarrays.

ANALYSIS ON DEMAND

 Multifactorial biostatistical analysis of epidemiological and clinical basis.  Identification and validation of diagnostic and prognostic biomarkers.  Identification of biomarkers of differential response to drugs and new pharmacological targets.  Nutrigenomic studies of differential response to nutrients and physiological models.  Data mining (analysis of cluster or groups of data records, detection of anomalies and detection of dependencies by associations).  Development of predictive algorithms (regression models, analysis of variance and covariance, time series, Bayesian methods, genetic algorithms, ad hoc classification (discriminant, decision trees, neural networks, etc.)  Analysis of genetic variation, selection and development of biological databases  Presentation of results in "ready to publish" format for presentations or articles: Tables, models and graphic representations according to the researcher's indications  Support to researchers to facilitate the passage of microarray technology to RNA -Seq / DNA-Seq and normalization of data between both techniques.

CUSTOMERS

Some of the clients with whom we have carried out genomic research are, for example, INCLIVA, Instituto d Investigación Sanitaria Pere VirgiIi, Universidad del País Vasco, IDIBAPS, Universidad de Navarra, Hospital Universitario de la Princesa, Hospital Materno Infantial San Joan de Déu, Instituto de Investigación Sanitaria la Fe, and Fundación Jimenéz Díaz, among others.
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